Endocrine Abstracts

Introduction: Glycogenic hepatopathy (GH) has been reported as a very rare and under recognized complication in longstanding poorly controlled type 1 diabetes patients. GH is characterised by transient elevation of liver transaminase and hepatomegaly caused by reversible and excessive glycogen accumulation in hepatocytes. Here we report a 20 years old type 1 poorly controlled diabetic female patient with elevated transaminases.Clinical presentation: A 20...

A 73-year-old woman, admitted to emergency room due to generalized tonic–clonic seizures. She had a previous history of muscle cramps and paresthesia for 4 months. She had a medical history of peptic ulcer and she was taking omeprazole for 7 years. Her laboratory evaluation showed marked hypomagnesemia (<0.4 mg/dl normal ranges: 1.7–2.55 mg/dl) and hypocalcemia (6.83 mg/dl and normal ranges: 8.8–10.2 mg/dl) with extremely low urinary Ca and Mg excretion (&#6...

Objective: Diabetes is an independent risk factor for sudden cardiac death. Prolongation of the QT interval on the ECG increases the risk of arrhytmias and sudden death, and the increased prevalance of QT prolongation is an independent risk factor for cardiovascular death in diabetic patients. Low vitamin D levels are also associated with cardiovascular mortality. The aim of this study was to investigte the relationship between QT interval and vitamin D levels in type 2 diabet...

Objective: The risk of atherosclerotic heart disease is increased in hypothyroidism. Although the reason is not clear. It is known that high level of Lp(a) is increases the risk of atherosclerotic heart diseases. The aim of this study is to investigate the relation between Lp(a) levels and thyroid hormones in the Hashimato’s patients.Methods: One hundred and fifty Hashimato’s patient (50 patients diagnosed with clinic hypothryoid, 50 patients d...

Introduction: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit and it can be seen on postadolescence period. Several studies show that adrenal and pituitary hormones have an important role in the pathogenesis. The studies which show the isotretinoin treatment takes effect on hormones are phenomenal in the literature. The aim of our study is to identify a hormonal alteration in the etiopathogenesis of acne vulgaris and to observe whether there is an alt...

Introduction: Lymphocytic hypophysitis is an uncommon disease of the pituitary gland mimicking pituitary macroadenoma on magnetic resonance imaging (MRI).Case: A 37-year-old female admitted to our clinic with headache, amenorrhea, polyuria and history of pituitary microadenoma. On laboratory examinations, prolactin level was mildly elevated (42 ng/ml) and FSH–LH levels were normal (2.4–4.04 mIU/ml) despite the low estrogen level (<20 pg/ml)...

Introduction: Metformin-induced lactic acidosis (MALA) is one of the most important drug toxicities with high morbidity and mortality rates. Nonspecific symptoms such as nausea, vomiting, epigastric pain, hypotension, tachycardia, tachypnea, arrhythmia, renal insufficiency, coma and cardiac arrest can be seen. Here we are presenting a case with acidosis due to metformin overdose.Case: A 36-year-old female patient with a history of type 2 diabetes for thr...

Objectives: Acromegaly may arise with several clinical presentations and cardiac involvement is the most important factor affecting the course of the disease.Case: A 32-years old man admitted to hospital complaining with shortness of breath. After initial evaluation he was diagnosed as ‘cardiac failure’. Cardiac evaluation revealed that he had ‘dilated cardiomyopathy’ with ejection fraction (EF) of 20%, global hypokinesia without valv...

Background: Studies have shown that smoking may increase the risk of pancreatic disorders. This study aimed to evaluate the oxidative stress status, biochemical, pathological and immunohistochemical findings of rats exposed to the cigarette smoke, pathogenesis of smoking related pancreatic damage and usability of Alpha Lipoic Acid (ALA) for amelioration of cigarette’ harmful effects on rat pancreas.Methods: Twenty eight female, Sprague Dawley rats w...

Previous studies have shown increased hypoglycemia-associated cardiac arrhythmia and mortality in patients with type 2 diabetes and cardiovascular disease.In this study, we aimed to evaluate the response of gastrointestinal hormones and glucoregulatory hormones to the oral glucose tolerance test in patients who were diagnosed with reactive hypoglycemia and to evaluate the risk of arrhythmia with long-holter ECG measurements in patients with a diagnosis o...